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78. Y. Kawamata et al. Carbon Quaternization of Redox Active Esters and Olefins via Decarboxylative Coupling. ​ChemRxiv 10.26434/chemrxiv-2023-7vb8x

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77. van der Puyl-Lovett;† V. A.; Gan, X.-c.;† Kong, L.;† Shenvi, R. A. Single-catalyst alkene hydrobenzylation. ChemRxiv 10.26434/chemrxiv-2023-zw9c2 2023, †co-first authors.

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76. Kotesova, S.; Shenvi, R. A. Inner- and outer-sphere cross-couplings for high Fsp3 fragments in natural product space. Acc. Chem. Res. 2023, submitted.

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75. Ting, S.; Snelson, D.; Huffman, T. R.; Kuroo, A.; Sato, R.; Shenvi, R. A. Synthesis of (–)-cotylenol, a 14-3-3 molecular glue component. J. Am. Chem. Soc. 2023, 145, 20634.

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74. Kotesova, S.;§ Gan, X.-c.;§ Castanedo, A.; Green, S. A.; Møller, S. L. B.; Shenvi, R. A. Iron-catalyzed hydrobenzylation: stereoselective synthesis of (–)-eugenial C. J. Am. Chem. Soc. 2023, 145, 15714. §co-first authors

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73. Hill, S. J.§; Dao, N.§; Dang, V.; Stahl, E.; Bohn, L. Shenvi, R. A. A route to potent, selective and biased salvinorin chemical space. ACS Cent. Sci., 2023, online. §co-first authors

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72. Shenvi, R. A. Early Childhood Care as an Academic: The Slow Burn.  Angew. Chem. Int. Ed., 2023, in press [Ihr verborgenes Leben (Their Hidden Lives) Essay Series].

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68. Shevick, S. L.; Freeman, S.; Tong, G.; Russo, R. J.; Bohn, L. M.; Shenvi, R. A. Asymmetric syntheses of (+)- and (–)-collybolide enable re-evaluation of kappa-opioid receptor agonism ACS Cent. Sci., 2022, 8, 948–954. DOI: https://doi.org/10.1021/acscentsci.2c00442.

ChemRxiv DOI: 10.26434/chemrxiv-2021-rtxqf

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67. Woo, S.; Shenvi, R. A. Synthesis and target annotation of GB18. Nature, 2022, DOI: 10.1038/s41586-022-04840-9.

ChemRxiv DOI: 10.26434/chemrxiv-2022-cs8v5

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66. Landwehr, E. M.; Baker, M. A.; Oguma, T.; Burdge, H. E.; Kawajiri, T.; Shenvi, R. A. Concise syntheses of GB22, GB13 and himgaline by cross-coupling and complete reduction. Science, 2022, 375, 1270–1274.

ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1

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65. Huffman, B. J.; Chu, T.; Hanaki, Y.; Wong, J. J.; Chen, S.; Houk, K. N.; Shenvi, R. A. Stereodivergent attached ring synthesis via non-covalent interactions: a short formal synthesis of merrilactone A Angew. Chem. Int. Ed. 2022, 61, e202114514.

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64. Tong, G.; Shenvi, R. A. Revision of the unstable picrotoxinin hydrolysis product Angew. Chem. Int. Ed. 2021, 60, 19113.

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63. van der Puyl, V.; McCourt, R. O.; Shenvi, R. A. Cobalt-catalyzed alkene hydrogenation by reductive turnover  Tetrahedron Lett. 2021, 72, 153047. On the occasion of the 2020 Tetrahedron Prize to Dale Boger.

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62. Woo, S.; Shenvi, R. A. Natural Product Synthesis through the Lens of Informatics  Acc. Chem. Res. 2021, 54, 1157–1167. 

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61. Tong, G.; Baker, M. A.; Shenvi, R. A. Change the channel: CysLoop receptor antagonists from Nature.  Pest Manag. Sci. 2020, 77, 3650–3662. [Special Issue honoring Tom Sparks for the Kenneth Spencer Award]

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60. Shevick, S. L.; Wilson, C. V.; Kotesova, S.; Kim, D.; Holland, P. L.; Shenvi, R. A. Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals. Chem. Sci. 2020, 12401–12422. 

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59. Demoret, R. M.; Baker, M. A.; Ohtawa, M.; Chen, S.; Lam, C.-C.; Khom, S.; Roberto, M.; Forli, S.; Houk, K.; Shenvi, R. A. Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (–)-Bilobalide. J. Am. Chem. Soc. 2020, 142, 18599–18618.ChemRxiv DOI: 10.26434/ chemrxiv.12132939.v2

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58. Hill, S. J.; Brion, A. U. C. M.; Shenvi, R. A. Chemical Syntheses of the salvinorin chemotype of KOR agonist. Nat. Prod. Rep. 2020, 37, 1478–1496.

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57. Crossley, S. W. M.; Tong, G.; Lambrecht, M. J.; Burdge, H. E.; Shenvi, R. A.  Total Synthesis of (–)-Picrotoxinin J. Am. Chem. Soc. 2020, 142, 11376–11381.

ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1

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56. Matos, J. L. M.; Green, S. A.; Chun, Y; Dang, V. Q.; Dushin, R. G.; Richardson, P.; Chen, J. S.; Piotrowski, D. W.; Paegel, B. M.; Shenvi, R. A. Cycloisomerization of olefins in water, Angew. Chem. Int. Ed. 2020, 59, 12998–13003.

ChemRxiv: 10.26434/chemrxiv.11977917.v1

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55. Burdge, H. E.; Oguma, T.; Kawajiri, T.; Shenvi, R. A. Concise Synthesis of GB22 by Endo-Selective Siloxycyclopropane Arylation ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1 .

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54. Huffman, B. J.; Chen, S.; Schwarz, J. L; Plata, R. E.; Chin, E.; Houk, K. N.; Lairson, L. L.; Shenvi, R. A. Electronic Complementarity Permits Hindered Butenolide Heterodimerization and Discovery of Novel cGAS/STING Pathway Antagonists, Nature Chem. 2020, 12, 310–317.

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53. Shevick, S. L.; Baker, M. A.; Shenvi, R. A. Alkene Hydroarylation by Co/Ni Dual Catalysis, Cell: Trends in Chemistry, 2019, 1, 540–541.

52. Matos, J. L. M.; Green, S. A.; Shenvi, R. A. Chapter 7. Markovnikov Functionalization by Hydrogen Atom Transfer, Organic Reactions, 2019, 100, 383–470.

51. Baker, M.; Demoret, R.; Ohtawa, M.; Shenvi, R. A. Concise Asymmetric Synthesis of (–)-Bilobalide Nature 2019, 575, 643–646. DOI: 10.1038/s41586-019-1690-5. ChemRxiv DOI: 10.26434/chemrxiv.8202053.v1 Featured in Org. Chem. Highlights

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50. Green, S. A.; Huffman, T. R.; McCourt, R. O.; van der Puyl, V.; Shenvi, R. A.  Hydroalkylation of Olefins to form Quaternary Carbons J. Am. Chem. Soc. 2019, 141, 7709-7714.

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49. Martinez, R.; Burdge, H.; Shenvi, R. A. Reanalysis of Lindenatriene, a Building Block for the Synthesis of Lindenane Oligomers Tetrahedron 2019, 75, 3140-3144. [invited manuscript for Ryan's Tetrahedron Young Investigator Award 2019]

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48. Huffman, B.; Shenvi, R.A. Natural Products in the 'Marketplace': Interfacing Synthesis and Biology J. Am. Chem. Soc. 2019, 141, 3332-3346.

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47. Huffman, T.; Wu, Y.; Emmerich, A.; Shenvi, R.A. Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates Angew. Chem. Int. Ed. 2019, 58, 2371-2376.

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46. Matos, J.L.M.; Vásquez-Céspedes, S.; Gu, J.; Oguma, T.; Shenvi, R.A. Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes J. Am. Chem. Soc. 2018, 140, 16976–16981.

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45. Green, S.A.; Crossley, S.W.M.; Matos, J.L.M.; Vásquez-Céspedes, S.; Shevick, S. L.; Shenvi, R. A. The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer Acc. Chem. Res., 2018, 51, 2628–2640. 

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44. Shevick, S. L.; Obradors, C.; Shenvi, R. A. Mechanistic Interrogation of Co/Ni-Dual Catalyzed Hydroarylation J. Am. Chem. Soc. 2018,140, 12056–12068. 

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43. Green, S. A.; Vásquez-Céspedes, S.; Shenvi, R. A. Iron-Nickel Dual-Catalysis: A New Engine for Olefin Functionalization. J. Am. Chem. Soc. 2018, 140, 11317–11324 

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42. Jeffrey M. Witkin, Ryan A. Shenvi, Xia Li, Scott D. Gleason, Julie Weiss, Denise Morrow, John T. Catow, Mark Wakulchik, Masaki Ohtawa, Hai-Hua Lu, Michael D. Martinez, Jeffrey M. Schkeryantz, Timothy S. Carpenter, Felice C. Lightstone, Rok Cerne Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies. Biochem. Pharm. 2018, 155, 61–70. 

DOI: 10.1016/j.bcp.2018.06.022

41. Lambrecht, M.; Kelly, J. W.; Shenvi, R. A. Mechanism of Action of the Cytotoxic Asmarine Alkaloids. ACS Chem. Bio. 2018, 13, 1299–1306. DOI: 10.1021/acschembio.8b00096

38. Roach, J. J.; Sasano, Y.; Schmid, C. L.; Zaidi, S.; Katrich, V.; Stevens, R. C.; Bohn, L. M.; Shenvi, R. A. Dynamic Strategic Bond Analysis Yields a 10-step Synthesis of 20-nor-SalA, a Potent Κ-OR Agonist. A(CS)2 2017, 3, 1329–1336.

ChemRxiv DOI: 10.26434/chemrxiv.5318188

  • #1 Most Viewed Article on ChemRxiv, Aug-Dec 2017.

  • Highlighted by Tien Ngyuen in C&EN, Sept. 1 2017.

  • See article on SlashGear by Brittany Rosen, Sept. 11, 2017

  • See article on Gizmodo by Ryan Mandalbaum, Sept. 12, 2017

  • See article on Geek by Daniel Starkey, Sept. 12, 2017

  • See article on Wired by Matthew Simon, Jan. 8, 2018

34. Shenvi, R. A. And You, of Tender Years. Chem. 2016, 1, 331.

27. Shenvi, R. A. Reinventing Radical Reactions. SynLett Cluster (Ed. T. Rovis and R. A. Shenvi). 2016, 27, 678-679.

20. Crossley, S. W. M.; Barabé, F.; Shenvi, R. A. Simple, Chemoselective, Catalytic Olefin Isomerization. J. Am. Chem. Soc. 2014, 136, 16788.​

Isomerization pre-catalyst now available from Sigma-Aldrich

17. Pronin, S. V.; Reiher, C. A.; Shenvi, R. A. Stereoinversion of tertiary alcohols to tertiary alkyl isonitriles and amines. Nature. 2013, 501, 195-199.

  • Featured by TCI Chemicals

  • Highlighted by Bethany Halford in C&EN 2013, 91, 8.

  • Highlighted by Stephen Davey in Nature Chemistry 2013, 5, 808.

  • Highlighted by A. Räder and K. Tiefenbacher: Angew. Chem. Int. Ed. 2013, 52, 2.

  • Selected for highlight in C&EN: “2013’s Notable Advances” 2013, 91, 15.

13. Pronin, S. V.; Tabor, M. G.; Jansen, D. J.; Shenvi, R. A. A Stereoselective Hydroamination Transform to Access Polysubstituted Indolizidines. J. Am. Chem. Soc. 2012, 134, 2012-2015. 

• In top ten most accessed articles of J. Am. Chem. Soc. for January 2012.

• Highlighted in Nature Chemistry, May 2012.

Postdoctoral, Graduate and Undergraduate

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12. Shi, J.; Manolikakes; G. Yeh, C.-H.; Guerrero, C. A.; Shenvi, R. A.; Shigehisa, Hiroki; Baran, P. S. Scalable Synthesis of Cortistatin A and Related Structures. J. Am. Chem. Soc. 2011, 133, 8014-8027.

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11. Shenvi, R. A.; Corey, E. J. Synthetic Access to Bent Polycycles by Cation-Pi Cyclization. Org. Lett. 2010, 12, 3548-3551.

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10. Shenvi, R. A.; Corey, E. J. A Short and Efficient Synthesis of (–)-7-Methylomuralide, a Potent Proteasome Inhibitor. J. Am. Chem. Soc., 2009, 131, 5746-5747.

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9. Shi, J.; Shigehisa, H.; Guerrero, C. A.; Shenvi, R. A.; Li, R. A.; Baran, P. S. Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues. Angew. Chem. Int. Ed. 2009, 48, 4328-4331.

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8. Shenvi, R. A.; O’Malley, D. P.; Baran, P. S. Chemoselectivity: The Mother of Invention in Total Synthesis. Acc. Chem. Res. 2009, 42, 530-541.

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7. Shenvi, R. A. (2008). Pure and Applied Science in the Chemical Syntheses of Marine Alkaloids Chartelline C and Cortistatin A. Ph.D. Thesis, The Scripps Research Institute, 2008.

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6. Shenvi, R. A.; Guerrero, C. A.; Shi, J.; Li, C.-C.; Baran, P. S. Synthesis of (+)-Cortistatin A. J. Am. Chem. Soc. 2008, 130, 7241-7243.

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5. Baran, P. S.; Shenvi, R. A. Total Synthesis of (±)-Chartelline C. J. Am. Chem. Soc. 2006, 128, 14028-14029.

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4. Baran, P. S.; Shenvi, R. A.; Nguyen, S. A. One-Step Synthesis of 4,5-Disubstituted Pyrimidines Using Commercially Available and Inexpensive Reagents. Heterocycles. 2006, 70, 581-586.

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3. Baran, P. S.; Shenvi, R. A., Mitsos, C. A. A Remarkable Ring Contraction En Route to the Chartelline Alkaloids. Angew. Chem. Int. Ed. 2005, 44, 3714-3717.

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2. Shenvi, R. A.; Funk, R. L. (2003). An approach to the synthesis of the potent antimicrotubule agent ottelione (RPR112378). B.S. Thesis, Pennsylvania State University, 2003.

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1. Ababou, A.; Shenvi, R. A.; Desjarlais, J. R. Long-Range Effects on Calcium Binding and Conformational Change in the N-Domain of Calmodulin. Biochemistry 2001, 40, 12719-12726.

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