We are a group of chemists interested in using chemical synthesis to make structurally complex and distinct chemical structures.  These structures inspire and challenge us to develop novel methodologies that greatly enhance the methods that are available to chemists.  As chemists, our unique access to structure enables us to probe function and answer questions about the biological origins of these molecules and mechanisms of action.  Find out more about what we do and who we are.  

Topologically complex and diverse chemical structure paired with unique biological origins and mechanisms of actions serve to challenge and inspire basic and applied research.

with the goal of understanding the unique biological origins of these molecules and mechanisms of action in humans. 

Structurally complex and distinct chemical structures with the goal of understanding the unique biological origins of these molecules and mechanisms of action in humans.

Lab News

January 31, 2019

Nobody's perfect, and neither are natural products. Check out our JACS perspective on how exploring natural product-like space leads to innovative changes to NP scaffolds, while providing opportunities for exciting chemistry.  Thanks to Ben for this thoughtful perspective!

January 31, 2019

Great work by Tucker, Jackie and Alexis on the intermolecular arylation of tetrasubstituted alkenes published in Angewandte Chemie!  A great example of how synthesis can lead to new methodology (and a shameless plug to check out our 20-nor-SalA synthesis).

January 29, 2019

The lab says goodbye to undergraduate Kelly Chen, who will be returning to Nankai University to finish her bachelor's degree.  Good luck!

December 14, 2018

Best of luck to Suhelen, who will be joining the Process team at Dow AgroSciences in Indianapolis!  Thank you for all of your contributions to the lab -- we will miss you!

December 07, 2018

The lab bids farewell to post-doc Mike!  We wish him luck as he heads to Genentech Medicinal Chemistry.

November 30, 2018

Auf Wiedersehen to Stefanie!  We look forward to following your future work in the literature.

November 22, 2018

MHAT bimetallic catalysis continues!  Our work on branch-selective addition of olefins into imines and aldehydes has been accepted to JACS.  Great work by Jeishla, Suhelen, Jess (Baran Lab first-year) and Takuya.

November 08, 2018

Chemofidelity (noun): reliable reactivity independent of molecular context.  Read more about it in the context of metal-catalyzed hydrogen atom transfer in Accounts of Chemical Research.  

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Find us at:

Beckman Center for Chemical Sciences

10550 N. Torrey Pines Road

La Jolla, CA   92037

email | phone: 858.784.8415